Poster Title
Faculty Advisor
Dr. James Wollack
Department
Chemistry
Abstract
An analog of an antibiotic ester was synthesized by a direct condensation between a carboxylic acid, 6-hydroxy-2-napthoic acid, and methanol, using a newly discovered reusable catalyst, HClO4-SiO4. A butyl group was added to the resulting ester by Williamson ether synthesis to yield methyl 6-butoxy-2-naphthoate. A microbial test using E. coli was used to test the antimicrobial activity of the synthesized ester and the product of the Williamson ether synthesis. Green chemistry was used to make the first step of this reaction go faster using the synthesized catalyst HClO4-SiO4.
Start Date
19-4-2012 11:00 AM
End Date
19-4-2012 1:00 PM
Synthesis of an Antimicrobial Agent
An analog of an antibiotic ester was synthesized by a direct condensation between a carboxylic acid, 6-hydroxy-2-napthoic acid, and methanol, using a newly discovered reusable catalyst, HClO4-SiO4. A butyl group was added to the resulting ester by Williamson ether synthesis to yield methyl 6-butoxy-2-naphthoate. A microbial test using E. coli was used to test the antimicrobial activity of the synthesized ester and the product of the Williamson ether synthesis. Green chemistry was used to make the first step of this reaction go faster using the synthesized catalyst HClO4-SiO4.