Hox Protein Function in Patterning C. Elegans Neuronal Cell Fates

Andrea Kalis, St. Catherine University
Seanna Loeb, St. Catherine University

Project Description

Hox genes are key transcription factors that bind to regulatory regions of genes, determine cell fate, and promote or inhibit transcription. This project aims to understand how one Hox gene, lin-39, and its mutant form, lin-39(ccc16), regulate the fate of neuronal cells using the model organism Caenorhabditis elegans (C. elegans). Lin-39(ccc16) fails to specify cell fates in certain circumstances. Therefore, we will determine how lin-39(ccc16) is different from the normal lin-39, which will help us understand the molecular mechanism of the Hox gene regulation.