Date of Paper/Work


Type of Paper/Work

Scholarly project

Degree Name

Master of Arts in Nursing




Vicki Ericson


Chronic obstructive pulmonary disease (COPD) is a chronic and progressive disease that has been associated with high mortality rates and is now becoming an economic burden on public health (WHO, 2012). Tiotropium and long-acting beta2-agonists (LABA) are both utilized in managing patients with COPD. However, guidelines do not specify which medication is the drug of choice. To investigate the efficacy of LABA versus Tiotropium, a search of the current literature was undertaken. The database utilized was the Cochrane Library. Three systematic reviews were found and all included randomized control trials with similar methodology. Based on the analysis and synthesis of these reviews, no valid conclusions could be drawn with regard to the superiority of tiotropium or LABA in managing quality outcomes. Implications for clinical practice include possibly prescribing both tiotropium and a LABA for a trial period to allow the patient to decide which medication is better.